Anastrozole Oral: Uses, Side Effects, Interactions, Pictures, Warnings & Dosing

Anastrozole tablets are indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer. Patients with pre-existing ischemic heart disease should be informed that an increased incidence of cardiovascular events has been observed with anastrozole use compared to tamoxifen use. Advise patients if new or worsening chest pain or shortness of breath occurs to seek medical attention immediately [see Warnings and Precautions (5.1)] . Anastrozole caused embryo-fetal toxicities in rats at maternal exposure that were 9 times the human clinical exposure, based on area under the curve (AUC).

• Do not stop taking any of your medicines unless they tell you to.
• Time to progression and objective response (only patients with measurable disease could be considered partial responders) rates were the primary efficacy variables.
• They can help determine the best treatment option for your condition and what to expect from your treatment.
• Verify the pregnancy status of females of reproductive potential prior to initiation of anastrozole.
• Talk with your doctor about how much alcohol, if any, is safe for you to drink during your Arimidex treatment.
• If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them.

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To learn about other mild side effects, talk with your doctor or pharmacist or read Arimidex’s prescribing information. Arimidex is used to treat certain forms of breast cancer. By blocking this change, Arimidex decreases the amount of estrogen in your body. Arimidex may decrease blood flow to your heart, especially if you have ever had coronary artery disease (clogged arteries).

Anastrozole does not possess direct progestogenic, androgenic, or estrogenic activity in animals, but does perturb the circulating levels of progesterone, androgens, and estrogens. The effect of anastrozole in premenopausal women with early or advanced breast cancer has not been studied. A randomized, double-blind, placebo-controlled, multi-center study enrolled 80 boys with pubertal gynecomastia aged 11 to 18 years. Patients were randomized to a daily regimen of either anastrozole 1 mg or placebo.

2 First Line Therapy in Postmenopausal Women with Advanced Breast Cancer

This side effect was only reported in people taking the drug for advanced breast cancer. Arimidex lowers estrogen levels in postmenopausal women, which may slow the growth of certain types of breast tumors that need estrogen to grow in the body. These are not all the possible side effects of anastrozole tablets. For more information, ask your healthcare provider or pharmacist. Anastrozole had no inhibitory effect on reactions catalyzed by cytochrome P450 2A6 or 2D6 in vitro. In multiple daily dosing trials with 5 and 10 mg, thyroid stimulating hormone (TSH) was measured; there was no increase in TSH during the administration of anastrozole.

The pharmacokinetics of anastrozole are not affected by age. Oxymetholone muscle building The background risk of major birth defects and miscarriage for the indicated population is unknown. In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Selected from data included with permission and copyrighted by First Databank, Inc.

Patients receiving anastrozole had a higher incidence of carpal tunnel syndrome [78 (2.5%)] compared with patients receiving tamoxifen [22 (0.7%)]. If any of these effects last or get worse, tell your doctor or pharmacist promptly. If it does not get better, your doctor, nurse or pharmacist can prescribe drugs to control it.